
Removal of multiple nodes has been standard practice, but a study finds it doesn't affect survival rates. The procedure can have side effects.
Some women with early-stage breast cancer may be cured without the need to remove multiple lymph nodes, which has been the standard practice, researchers reported Tuesday.Breast cancer surgery traditionally includes removal of lymph nodes near the tumor so that doctors can check for evidence that the cancer has spread. However, a new study found that people with early-stage breast cancer that has spread to a nearby lymph node fared just as well after treatment without the removal of additional lymph nodes in the armpit area.
Taking out those extra nodes, called axillary nodes, has a distinct downside because it can leave some women with swelling and stiffness in the arm.
The study, published in the Journal of the American Medical Assn., examined 891 patients who had an early-stage tumor. All of the patients had their tumors removed via lumpectomy — meaning just part of the breast is removed, not the entire breast — and then had radiation therapy. Most of the women also had chemotherapy.
All the women in the study had evidence of cancer in the one or two nodes closest to the tumor, known as the sentinel lymph nodes. In about half of the women, however, doctors also removed at least 10 axillary lymph nodes. The average number of axillary nodes removed was 17.
Cancer was found in the axillary lymph nodes in 27% of the women in the study. Nevertheless, after an average of about six years, the study showed little difference in cancer recurrence or survival between the women who had many nodes removed and those who had only the sentinel nodes removed.
The five-year survival rate was 91.8% in the women with axillary-node removal, compared with 92.5% with sentinel-node-only removal. This difference was not statistically significant.
As expected, the patients who had axillary nodes removed had more complications from surgery, including infections and swelling. Swelling from excess fluid in the lymph tissue, called lymphedema, can persist long after recovery from the cancer, noted the authors of the study, which was led by Dr. Armando E. Giuliano of the John Wayne Cancer Institute atSt. John's Health Center in Santa Monica.
The findings add to a collection of studies that "have shown that less surgery combined with more radiation and chemotherapy have improved survival for women with breast cancer," said Dr. Grant Walter Carlson and Dr. William C. Wood of Emory University in Atlanta, the authors of a commentary accompanying the study.
Moreover, they said, because survival rates were so high at the five-year mark, it is unlikely that differences in the two groups' survival rates will arise at the 10-year mark or later.
"This is really a move toward less radical surgery" for breast cancer patients, Giuliano said.
Lymph nodes are tiny structures linked by a network of vessels throughout the body that are part of the disease-fighting immune system. When cancer spreads, it typically travels first to nearby nodes.
About a third of the women diagnosed every year with breast cancer have disease that has spread to the lymph nodes, the National Cancer Institute said.
shari.roan@latimes.com
Times wire services contributed to this report.Copyright © 2011, Los Angeles Times

The food police may find this hard to take, but chocolate has gotten a bad rap. People say it causes acne, that you should eat carob instead, that it's junk food. But these accusations are not only undeserved and inaccurate, they falsely incriminate a delicious food that turns out to have profoundly important healing powers.There is in fact a growing body of credible scientific evidence that chocolate contains a host of heart-healthy and mood-enhancing phytochemicals, with benefits to both body and mind.For one, chocolate is a plentiful source of antioxidants. These are substances that reduce the ongoing cellular and arterial damage caused by oxidative reactions.You may have heard of a type of antioxidants called polyphenols. These are protective chemicals found in plant foods such as red wine and green tea. Chocolate, it turns out, is particularly rich in polyphenols. According to researchers at the University of Texas Southwestern Medical Center in Dallas, the same antioxidant properties found in red wine that protect against heart disease are also found in comparable quantities in chocolate.How does chocolate help to prevent heart disease? The oxidation of LDL cholesterol is considered a major factor in the promotion of coronary disease. When this waxy substance oxidizes, it tends to stick to artery walls, increasing the risk of a heart attack or stroke. But chocolate to the rescue! The polyphenols in chocolate inhibit oxidation of LDL cholesterol.And there's more. One of the causes of atherosclerosis is blood platelets clumping together, a process called aggregation. The polyphenols in chocolate inhibit this clumping, reducing the risks of atherosclerosis.High blood pressure is a well known risk factor for heart disease. It is also one of the most common causes of kidney failure, and a significant contributor to many kinds of dementia and cognitive impairment. Studies have shown that consuming a small bar of dark chocolate daily can reduce blood pressure in people with mild hypertension.Why are people with risk factors for heart disease sometimes told to take a baby aspirin every day? The reason is that aspirin thins the blood and reduces the likelihood of clots forming (clots play a key role in many heart attacks and strokes). Research performed at the department of nutrition at the University of California, Davis, found that chocolate thins the blood and performs the same anti-clotting activity as aspirin. "Our work supports the concept that the chronic consumption of cocoa may be associated with improved cardiovascular health," said UC Davis researcher Carl Keen.How much chocolate would you have to eat to obtain these benefits? Less than you might think. According to a study published in the American Journal of Clinical Nutrition, adding only half an ounce of dark chocolate to an average American diet is enough to increase total antioxidant capacity 4 percent, and lessen oxidation of LDL cholesterol.Why, then, has chocolate gotten such a bum reputation? It's the ingredients we add to it. Nearly all of the calories in a typical chocolate bar are sugar and fat.As far as fats go, it's the added fats that are the difficulty, not the natural fat (called cocoa butter) found in chocolate. Cocoa butter is high in saturated fat, so many people assume that it's not good for your cardiovascular system. But most of the saturated fat content in cocoa butter is stearic acid, which numerous studies have shown does not raise blood cholesterol levels. In the human body, it acts much like the monounsaturated fat in olive oil.Milk chocolate, on the other hand, contains added butterfat which can raise blood cholesterol levels. And it has less antioxidants and other beneficial phytochemicals than dark chocolate.Does chocolate contribute to acne? Milk chocolate has been shown to do so, but I've never heard of any evidence incriminating dark chocolate.Dark chocolate is also healthier because it has less added sugar. I'm sure you don't need another lecture on the dangers of excess sugar consumption. But if you want to become obese and dramatically raise your odds of developing diabetes, heart disease, cancer and Alzheimer's disease, foods high in sugar (including high fructose corn syrup) are just the ticket.Are chocolate's benefits limited to the health of the body? Hardly. Chocolate has long been renown for its remarkable effects on human mood. We are now beginning to understand why.Chocolate is the richest known source of a little-known substance called theobromine, a close chemical relative of caffeine. Theobromine, like caffeine, and also like the asthma drug theophylline, belong to the chemical group known as xanthine alkaloids. Chocolate products contain small amounts of caffeine, but not nearly enough to explain the attractions, fascinations, addictions, and effects of chocolate. The mood enhancement produced by chocolate may be primarily due to theobromine.Chocolate also contains other substances with mood elevating effects. One is phenethylamine, which triggers the release of pleasurable endorphins and potentates the action of dopamine, a neurochemical associated with sexual arousal and pleasure. Phenethylamine is released in the brain when people become infatuated or fall in love.Another substance found in chocolate is anandamide (from the Sanskrit word "ananda," which means peaceful bliss). A fatty substance that is naturally produced in the brain, anandamide has been isolated from chocolate by pharmacologists at the Neurosciences Institute in San Diego. It binds to the same receptor sites in the brain as cannabinoids -- the psychoactive constituents in marijuana -- and produces feelings of elation and exhilaration. (If this becomes more widely known, will they make chocolate illegal?)If that weren't enough, chocolate also boosts brain levels of serotonin. Women typically have lower serotonin levels during PMS and menstruation, which may be one reason women typically experience stronger cravings for chocolate at these times in their cycles. People suffering from depression so characteristically have lower serotonin levels that an entire class of anti-depressive medications called serotonin uptake inhibitors (including Prozac, Paxil, and Zooloft) have been developed that raise brain levels of serotonin.Since I am known as an advocate of healthy eating, I'm often asked about my food indulgences. One of my favorite desserts is a piece of dark organic chocolate, along with a glass of a fine red wine.I do have a policy, though, to eat only organic and/or fair trade chocolate. This is because of what I have learned about child slavery in the cocoa trade.May your life be full of healthy pleasures.
New research published online today in the journalScience found that newborn mice can regenerate working heart tissue.So what's the big whoop? Scientists already knew that certain amphibians and fish could regenerate cardiac tissue.Well that, it turns out, is what inspired researchers at the Southwestern Medical Center in Texas to consider the possibility that mammalian hearts could also regenerate. Given the similarities in the hearts of adult zebrafish -- which can regrow tissue -- and immature mammals, researchers wondered if they couldn't "conserve," as they put it, the same mechanisms of regeneration in mice.The results? Within 21 days of scientists surgically removing a portion of the left ventricular apex from newborn mice, the tissue had completely regenerated. The problem, though, is that researchers found mice lost the capacity to regenerate cardiac tissue by the time they were seven days old.The potential implications, the scientists report, is this: "For a brief period after birth, the mammalian heart appears to have the capacity to regenerate." Which means, according to The Guardian, potentially very good things for heart attack sufferers."Now that we know that the mammalian heart indeed possesses the potential to regenerate, at least early in life," Eric Olson, one of the study's authors told The Guardian, "we can begin to search for drugs or genes or other things that might reawaken this potential in the adult heart of mice and eventually of humans."Shared from: The Huffington Post
